Xtandi 40mg Capsule (Enzalutamide)
Prescription RequiredManufactured By
Astellas
Pack Of
120
Salt Composition
Enzalutamide
Storage
Keep in cold place
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Overview
Xtandi 40mg Capsule is a prescription-based anticancer medicine used in the treatment of advanced-stage prostate cancer, including metastatic castration-resistant prostate cancer, non-metastatic castration-resistant prostate cancer, and metastatic hormone-sensitive prostate cancer. The active ingredient of the Xtandi is enzalutamide, which belongs to the drug class of androgen receptor inhibitors. It works by blocking the effect of natural male hormones called androgens, particularly testosterone, to control the growth & multiplication of cancer cells. Enzalutamide 40mg Capsule is used alone and also given in combination with another anticancer medicine as a part of combination therapy to increase the efficacy of the treatment.
The capsule must be taken orally and swallowed whole with water and should not be crushed, chewed, or opened. The prescribed dose and duration of the Enzalutamide 40mg capsule depend on the patient's condition and response to treatment. It can also be taken with or without food. Patients are advised not to change the dosage and timings prescribed by the doctors because it can cause severe side effects.
Common side effects include tiredness, weakness, hot flushes, headache, dizziness, joint or muscle pain, decreased appetite, and high blood pressure. A few patients can undergo severe side effects, including severe headache with confusion or vision changes, difficulty breathing and swelling of the face or throat. Most of the Enzalutamide 40mg capsule side effects can leave when the body adapts to the medicine. However, report to your doctor if you experience serious side effects.
Patients should use effective contraception because the medicine may harm a developing fetus. Patients must list all medicines, supplements, and herbal products that they are taking. The Enzalutamide 40mg Capsule must be used under medical oversight or medical supervision only. Attend regular tests and follow-ups to monitor the medicine response and reduce side effects. Before making any adjustments, changing the dose, or stopping the treatment, consult with your doctor to maximize the benefit.
Indication
Prostate Cancer
Side Effects
The human body shows undesired symptoms after taking Enzalutamide 40mg Capsule (Xtandi). Usually, they disappear with time as the body adjusts to the medicine. These side effects don't need special medical attention. It is advised to consult your doctor if these symptoms become unmanageable.
Some of the common side effects of Xtandi Capsule are mentioned below:
● Anemia
● Diarrhea
● Anxiety
● Constipation
● Low sex drive
● Loss in appetite
● Breathlessness
● Fall and fractures
● Body and back pain
● Nausea & Vomiting
● Weakness & dizziness
● Rashes and skin allergy
● Heavy urination during the night
Serious Side Effects
- ● Blood in urine
- ● Heart problem
- ● High blood pressure
- ● Enlarged breasts in men
- ● Difficulty in concentration
- ● Increased blood sugar level
- ● Increase in liver enzyme level
How To Use
Xtandi 40mg Capsule (Enzalutamide) is a prescription-based anticancer drug that should be administered orally. It is advised to take this capsule/tablet after consulting your healthcare expert.
This capsule should be swallowed as a whole with water. Don't crush, chew, or break it. It can be taken with or without food. Never skip a dose or double dose.
Reference
● Davis, I. D., Martin, A. J., Stockler, M. R., Begbie, S., Chi, K. N., Chowdhury, S., ... & Sweeney, C. J. (2019). Enzalutamide with standard first-line therapy in metastatic prostate cancer. New England Journal of Medicine, 381(2), 121-131.
● Scher, H. I., Fizazi, K., Saad, F., Taplin, M. E., Sternberg, C. N., Miller, K., ... & de Bono, J. S. (2012). Increased survival with enzalutamide in prostate cancer after chemotherapy. New England Journal of Medicine, 367(13), 1187-1197.
● Scott, L. J. (2018). Enzalutamide: A Review in Castration-Resistant Prostate Cancer. Drugs, 78(18), 1913.
● Scher, H. I., Fizazi, K., Saad, F., Taplin, M. E., Sternberg, C. N., Miller, K., ... & de Bono, J. S. (2012). Increased survival with enzalutamide in prostate cancer after chemotherapy. New England Journal of Medicine, 367(13), 1187-1197.
● Armstrong, A. J., Azad, A. A., Iguchi, T., Szmulewitz, R. Z., Petrylak, D. P., Holzbeierlein, J., ... & Stenzl, A. (2022). Improved survival with enzalutamide in patients with metastatic hormone-sensitive prostate cancer. Journal of Clinical Oncology, 40(15), 1616-1622.
Safety Advice
- • Alcohol: The interaction of alcohol with this drug is still unknown. It is advisable not to consume alcohol while taking Enzalutamide 40mg Capsule (Xtandi). It is advised to consult your doctor for further information.
- • Pregnancy: Xtandi 40mg Capsule (Enzalutamide) may be considered unsafe during pregnancy. Please consult your doctor in such condition.
- • Breastfeeding: Xtandi 40mg Capsule (Enzalutamide) is probably not safe if you're breastfeeding. Kindly consult your doctor.
- • Driving: It is advisable not to drive or operate heavy machinery as you may feel dizzy after taking Enzalutamide 40mg Capsule (Xtandi).
- • Kidney: Share your medical history with your healthcare expert in case of kidney disease before taking Xtandi 40mg Capsule (Enzalutamide).
- • Liver: Inform your doctor before starting Xtandi 40mg Capsule (Enzalutamide) if you have liver disease to avoid any serious side effects.
FAQs
What test must be done before going on treatment with Enzalutamide 40mg Capsule (Xtandi)?
Doctors will go for a Prostate Antigen Test (PSA), a protein secreted by the prostate gland that is responsible for men with prostate cancer. PSA level helps in deciding the treatment plan and how the body will respond to that.
Who should not take Xtandi 40mg Capsule (Enzalutamide)?
People who are allergic to its salt composition should avoid taking this medicine. Xtandi 40mg Capsule (Enzalutamide) is not recommended for pregnant or breastfeeding women because it can pass to the baby through mother.
Does Xtandi 40mg Capsule cause hair loss?
Hair loss is the most common side effect of using Xtandi 50mg tablet. Consult with your medical professional if you experience any other side effects such as blood in urine, loss of appetite, shortness of breath, abdominal pain, dark urine, skin rashes, and difficulty in urination.
What precautions should I take while taking Enzalutamide 40mg Capsule (Xtandi)?
Using Enzalutamide 40mg Capsule (Xtandi)causes light sensitivity. It is advised to avoid direct exposure to sunlight, sunbeds, sunlamps, and tanning. Use sunscreen before exposing to direct sunlight.
Can Xtandi 40mg Capsule (Enzalutamide) be given to a diabetic patient?
Xtandi 40mg Capsule should be used with precautions in patients with high blood sugar. It is advised to consult your doctor before taking the Xtandi Capsule.
Marketer Details
Astellas
Author Details
Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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