Vitrakvi 100mg Capsule (Larotrectinib)
Prescription RequiredManufactured By
Alleviare
Pack Of
60
Salt Composition
Larotrectinib
Storage
Keep in cold place
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ALL SUBSTITUTES
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Overview
Vitrakvi 100mg Capsule is a prescription-based anticancer medicine. It is used to treat solid tumors in adult and paediatric patients with Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion. It contains larotrectinib as an active ingredient, which belongs to a drug class known as tyrosine kinase inhibitor (TKI). It works by blocking the action of specific TRK proteins that regulate cancer cell growth. This can decrease cancer progression and cancer load. Doctors advise attending a molecular testing to confirm the presence of an NTRK gene fusion before treatment.
The capsule is taken orally and exactly as prescribed by the doctor. The capsule must be swallowed as whole with water and should not be crushed, chewed, or broken. It is usually taken with or without food. Larotrectinib 100mg Capsule is given twice daily, and a doctor decides the dose and timings according to the patient's condition, combination therapy, clinical response, and stage of cancer. Patients are advised not to change the dosage because it can lead to severe side effects.
Common side effects include tiredness, nausea, dizziness, vomiting, constipation, diarrhea, and increased liver enzymes. A few patients can undergo severe side effects, including confusion, dizziness, memory or concentration problems, mood changes, and coordination difficulties. Most of the Larotrectinib 100mg capsule side effects can leave when the body adapts to the medicine. However, report to your doctor if you experience serious side effects.
Larotrectinib can interact with CYP3A enzymes; therefore, review it before the treatment. Patients must list all medicines, supplements, and herbal products that they are taking. The Larotrectinib 100mg Capsule must be used under medical oversight or medical supervision only. Attend regular tests and follow-ups to monitor the medicine response and reduce side effects. Before making any adjustments, changing the dose, or stopping the treatment, consult with your doctor to maximize the benefit.
Indication
Adult and pediatric patients with solid tumors that have an NTRK gene fusion that are metastatic or where surgical resection is likely to result in severe morbidity, with no satisfactory alternative treatments.
Side Effects
Every medicine has some side effects that manage on their own as your body gets used to the medicine, but some people may rarely experience severe side effects. In that case, the patient should contact the doctor immediately.
Some common side effects of Vitrakvi 100mg Capsule (Larotrectinib 100mg) include:
● Fatigue or tiredness
● Nausea and vomiting
● Dizziness
● Cough
● Constipation or diarrhea
● Abnormal liver function tests (increased AST and ALT)
● Musculoskeletal (muscle, bone, or joint) pain
● Fever
● Anemia (low red blood cell count)
● Weight gain
● Decreased appetite
How To Use
The doctor determines the dosage and duration of the Vitrakvi 100mg Capsule (larotrectinib) as per the type of disease and overall health condition of the patients. Do not crush or break the capsule. This capsule may be taken with or without food. In case of an overdose, the doctor will provide emergency medical treatment. Do not stop or change the dose without informing your doctor.
Reference
● Ricciuti, B., Genova, C., Crinò, L., Libra, M., & Leonardi, G. C. (2019). Antitumor activity of larotrectinib in tumors harboring NTRK gene fusions: a short review on the current evidence. OncoTargets and therapy, 3171-3179.
● Scott, L. J. (2019). Larotrectinib: first global approval. Drugs, 79(2), 201-206.
● Raedler, L. A. (2019). Vitrakvi (Larotrectinib) First TRK Inhibitor Approved by the FDA for Solid Tumors Based on a Genetic Mutation.
● Bernsen, E. C., Hogenes, V. J., Nuijen, B., Hanff, L. M., Huitema, A. D., & Diekstra, M. H. (2022). Practical recommendations for the manipulation of kinase inhibitor formulations to age-appropriate dosage forms. Pharmaceutics, 14(12), 2834.
● Team, R. (2021). Larotrectinib (Vitrakvi). Canadian Journal of Health Technologies, 1(11).
Safety Advice
- ● Alcohol: Avoid the consumption of alcohol while taking Vitrakvi 100mg Capsule, as alcohol can reduce the effectiveness of the medicine and worsen the symptoms.
- ● Pregnancy: Vitrakvi 100mg Capsule(Larotrectinib 100mg) is not recommended during pregnancy as it is unsafe for the developing fetus. Doctors rarely prescribe this medicine in pregnancy.
- ● Breastfeeding: Vitrakvi 100mg Capsule is unsafe to use during breastfeeding as it may cause toxicity to the baby.
- ● Driving: Vitrakvi 100mg Capsule(Larotrectinib 100mg) may cause side effects such as dizziness or lack of concentration, which could affect your ability to drive. So it's better to avoid driving or operating heavy machinery.
- ● Kidney: Consumption of Vitrakvi 100mg Capsule should be avoided without informing the doctor if you have any kidney-related issues.
- ● Liver: Consumption of Vitrakvi 100mg Capsule(Larotrectinib 100mg) should be avoided without informing the doctor if you have any liver-related issues.
FAQs
What are the side effects of taking Vitrakvi 100mg Capsule?
Like any other anticancer medicine Vitrakvi 100mg Capsule (Larotrectinib) also shows some side effects like fatigue, tiredness, nausea, vomiting, dizziness, cough, constipation or diarrhea.
When should be Vitrakvi 100mg Capsule (Larotrectinib) prescribes?
The doctor prescribes Vitrakvi 100mg to treat solid tumors in patients with Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion.
Can a woman take this capsule while breastfeeding?
Try to avoid breastfeeding while taking Vitrakvi at least for one week after your last dose.
How to store Vitrakvi 100mg capsule?
Vitrakvi 100mg capsule (larotrectinib) should be stored at room temperature, usually between 68°F and 77°F (20°C and 25 C).
What is the active ingredient of Vitrakvi 100mg capsule?
The active ingredient of Vitrakvi 100mg is larotrectinib.
Marketer Details
Alleviare
Author Details
Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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